Daniel L Kastner Selected Research

Familial Mediterranean Fever (Periodic Disease)

1/2022	Excess Serum Interleukin-18 Distinguishes Patients With Pathogenic Mutations in PSTPIP1.
1/2021	Systematic evaluation of nine monogenic autoinflammatory diseases reveals common and disease-specific correlations with allergy-associated features.
1/2020	Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis.
1/2019	The Pyrin Inflammasome in Health and Disease.
1/2016	Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS.
1/2016	Old Dogs, New Tricks: Monogenic Autoinflammatory Disease Unleashed.
1/2016	Control of the innate immune response by the mevalonate pathway.
5/2013	Targeted resequencing implicates the familial Mediterranean fever gene MEFV and the toll-like receptor 4 gene TLR4 in Behçet disease.
10/2012	Rilonacept for colchicine-resistant or -intolerant familial Mediterranean fever: a randomized trial.
5/2011	Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice.

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Daniel L Kastner Research Topics

Disease

31	Inflammation (Inflammations) 12/2020 - 01/2003
20	Familial Mediterranean Fever (Periodic Disease) 01/2022 - 01/2003
13	Cryopyrin-Associated Periodic Syndromes 01/2022 - 12/2002
13	Fever (Fevers) 04/2021 - 09/2003
12	Rheumatoid Arthritis 02/2011 - 08/2004
8	Pyogenic arthritis, pyoderma gangrenosum, and acne 01/2022 - 01/2003
7	autosomal dominant familial Periodic fever 03/2012 - 08/2002
5	Mevalonate Kinase Deficiency 01/2022 - 09/2003
5	Autoimmune Diseases (Autoimmune Disease) 01/2020 - 08/2004
5	Infections 01/2019 - 06/2009
5	Exanthema (Rash) 12/2014 - 09/2003
4	VEXAS syndrome 01/2022 - 12/2020
4	Urticaria (Hives) 02/2016 - 10/2012
3	deficiency of adenosine deaminase 2 01/2022 - 01/2019
3	Necrosis 01/2022 - 01/2018
3	Enterocolitis 01/2022 - 10/2012
3	Arthralgia (Joint Pain) 10/2012 - 09/2003
2	Macrophage Activation Syndrome 01/2022 - 01/2016
2	Skin Diseases (Skin Disease) 01/2021 - 11/2015
2	Bites and Stings (Sting) 01/2021 - 01/2016
2	Lipodystrophy 01/2021 - 11/2015
2	Stroke (Strokes) 01/2021 - 12/2014
2	Chronic Inducible Urticaria 11/2020 - 02/2016
2	Arthritis (Polyarthritis) 12/2018 - 05/2008
2	Juvenile Arthritis (Juvenile Idiopathic Arthritis) 01/2018 - 12/2015
2	Disease Susceptibility (Diathesis) 01/2018 - 11/2015
2	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2017 - 09/2008
2	Rheumatic Diseases (Rheumatism) 07/2015 - 07/2012
2	Bronchiolitis 12/2014 - 10/2012
2	Schmid-Fraccaro syndrome 12/2014 - 03/2014
2	Common Variable Immunodeficiency 12/2014 - 01/2012
2	Behcet Syndrome (Behcet's Syndrome) 06/2014 - 05/2013
2	Injection Site Reaction 10/2012 - 03/2012
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 02/2011 - 08/2004
2	Amyloidosis 06/2006 - 09/2002
1	Vasculitis (Vasculitides) 01/2022
1	Multiple Myeloma 10/2021
1	Thrombocytopenia (Thrombopenia) 10/2021
1	Lymphopenia (Lymphocytopenia) 10/2021
1	Macrocytic Anemia 10/2021
1	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 10/2021
1	Headache (Headaches) 04/2021
1	Chronic Granulomatous Disease 04/2021
1	COVID-19 01/2021

Drug/Important Bio-Agent (IBA)

19	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2003
15	PyrinIBA 01/2022 - 12/2002
14	InflammasomesIBA 01/2022 - 09/2005
11	AutoantibodiesIBA 01/2020 - 12/2005
9	CytokinesIBA 01/2022 - 12/2002
7	Interleukin-1 (Interleukin 1)IBA 01/2022 - 12/2002
6	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 03/2011 - 08/2002
5	Adenosine DeaminaseIBA 01/2022 - 03/2014
5	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2022 - 12/2002
5	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 12/2017 - 06/2006
4	EnzymesIBA 10/2021 - 09/2003
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2012 - 09/2002
4	NF-kappa B (NF-kB)IBA 07/2009 - 11/2003
3	InterferonsIBA 01/2022 - 02/2011
3	Acute-Phase Proteins (Acute-Phase Protein)IBA 10/2021 - 06/2006
3	mevalonate kinaseIBA 01/2016 - 09/2003
3	DNA (Deoxyribonucleic Acid)IBA 09/2015 - 12/2002
3	AntigensIBA 06/2014 - 01/2009
3	Type I Tumor Necrosis Factor ReceptorsIBA 03/2011 - 08/2006
3	EpitopesIBA 12/2009 - 12/2005
3	Interleukin-1beta (Interleukin 1 beta)IBA 08/2008 - 09/2005
3	Anti-Citrullinated Protein AntibodiesIBA 05/2008 - 12/2005
2	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2021 - 03/2011
2	Tumor Necrosis Factor InhibitorsIBA 01/2021 - 01/2018
2	veltuzumabIBA 01/2021 - 01/2018
2	Protein Isoforms (Isoforms)IBA 12/2020 - 11/2004
2	InterleukinsIBA 12/2018 - 01/2018
2	Biological ProductsIBA 07/2017 - 03/2012
2	Transcription Factors (Transcription Factor)IBA 07/2017 - 07/2009
2	Cysteine (L-Cysteine)FDA Link 02/2016 - 09/2002
2	Mevalonic Acid (Mevalonate)IBA 01/2016 - 01/2005
2	HLA-DRB1 Chains (HLA DRB1)IBA 12/2015 - 12/2005
2	Phospholipases (Phospholipase)IBA 12/2014 - 10/2012
2	Interleukin-10 (Interleukin 10)IBA 05/2013 - 02/2013
2	rilonacept FDA Link 10/2012 - 08/2008
2	Etanercept (Enbrel)FDA Link 03/2012 - 09/2003
2	LipopolysaccharidesIBA 03/2011 - 11/2004
2	human PSTPIP1 proteinIBA 11/2010 - 11/2003
2	cyclic citrullinated peptideIBA 12/2009 - 12/2005
2	Rheumatoid FactorIBA 12/2009 - 12/2005
2	TNF Receptor-Associated Factor 1IBA 07/2009 - 09/2007
2	Protein Tyrosine PhosphatasesIBA 10/2005 - 08/2004
1	Indicators and Reagents (Reagents)IBA 01/2022
1	NucleotidesIBA 01/2022
1	Interleukin-18 (Interleukin 18)IBA 01/2022
1	Ubiquitin-Activating Enzymes (Ubiquitin-Activating Enzyme)IBA 01/2022
1	Codon (Codons)IBA 01/2022
1	Janus Kinase InhibitorsIBA 04/2021
1	AntibodiesIBA 04/2021
1	Ferritins (Ferritin)IBA 04/2021
1	SteroidsIBA 04/2021
1	tofacitinibIBA 04/2021
1	CalciumIBA 11/2020
1	Phosphatidylinositols (Phosphatidylinositol)IBA 11/2020

Therapy/Procedure

7	Therapeutics 01/2018 - 09/2002
1	Cell Transplantation 01/2021